U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study.

ABSTRACT:

Background

The modulation of lipid metabolism has been explored as a potential treatment for frailty, yet the association between non-high-density lipoprotein-cholesterol (non-HDL-C) and frailty remains unclear.

Methods

This study utilized data from five cycles of the National Health and Nutrition Examination Survey (NHANES) and two cycles of the China Health and Retirement Longitudinal Study (CHARLS) to investigate this relationship. A 40-item frailty index scale, encompassing various dimensions of somatic functioning, psychological evaluation, and illness, was developed and individually evaluated for each participant. The variables underwent screening through Least Absolute Shrinkage and Selection Operator (LASSO) regression, univariate logistic regression, and Light Gradi

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12135341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature