Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury.

ABSTRACT:

Background

Human mesenchymal stromal cells (MSCs) have potential as a treatment for inflammatory diseases, including acute lung injury (ALI), due to their anti-inflammatory and immunomodulatory properties. However, their clinical efficacy is often limited by poor post-transplant survival and adaptability in the host environment. Accordingly, MSCs are primed to boost their therapeutic efficacy for treating a variety of diseases. In our previous study, we discovered that culturing MSCs in a functional polymer-based 3D niche, which simulates the in vivo microenvironment, significantly increased integrin alpha 2 (ITGA2) expression compared to traditional 2D cultures, as revealed by RNA-seq analysis.

Methods

ITGA2 was used to prime MSCs and their therapeutic potential evaluated i

SUBMITTER: Kang H 

PROVIDER: S-EPMC12135379 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature