Prevalence and characteristics of tigecycline- and carbapenem-resistant <i>adeN</i>-truncated <i>Acinetobacter baumannii</i>: a genomic epidemiological analysis.

ABSTRACT: adeN-truncated Acinetobacter baumannii (ATAB) isolates are associated with elevated tigecycline resistance and enhanced virulence, yet its epidemic dynamics and genomic features remain poorly understood. This study aimed to investigate the epidemiology of ATAB isolates, identify infection risk factors, and assess their impact on patient prognosis. The prevalence of ATAB isolates in a tertiary care teaching hospital (Wenzhou, China) from January 2018 to December 2022 was determined via polymerase chain reaction (PCR) screening. Whole-genome sequencing and genomic analysis were conducted to explore the epidemiology and genomic characteristics of 254 ATAB isolates. Clinical data analysis was performed to identify risk factors for ATAB infection and its correlation with patient p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12135514 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature