Gametocyte production and transmission fitness of African and Asian <i>Plasmodium falciparum</i> isolates with differential susceptibility to artemisinins.

ABSTRACT: The emergence of Plasmodium falciparum parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in fitness costs. This study investigates the gametocyte production and transmission fitness of African and Asian P. falciparum isolates with different K13 genotypes across multiple mosquito species. We tested three ART-sensitive (ART-S) isolates (NF54, NF135, and NF180) and three ART-R isolates (ARN1G, 3815, and PAT-023) for sexual conversion and transmission to Anopheles stephensi, An. gambiae, and An. coluzzii. ART-R levels were quantified in vitro using the Ring-stage Survival Assay (RSA), and the transmission-reducing effects o

SUBMITTER: Proellochs NI 

PROVIDER: S-EPMC12135531 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature