Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight.

ABSTRACT:

Background

Equine dental diseases significantly impact a horse's overall health, performance and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH). Understanding EOTRH is crucial for early diagnosis, effective management and prevention of its severe consequences.

Objectives

To determine proteomic differences in incisor cementum in horses with and without clinical EOTRH.

Study design

Comparative and observational clinical study.

Methods

Teeth were extracted (N = 5) and cementum was isolated using a diamond wire. Proteins were extracted using an optimised sequential work

SUBMITTER: Jensen A 

PROVIDER: S-EPMC12135756 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature