The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila.

ABSTRACT: Sleep is a behavior that is conserved throughout the animal kingdom. Yet, despite extensive studies in humans and animal models, the exact function or functions of sleep remain(s) unknown. A complicating factor in trying to elucidate the function of sleep is the complexity and multiplicity of neuronal circuits that are involved in sleep regulation. It is conceivable that distinct sleep-regulating circuits are only involved in specific aspects of sleep and may underlie different sleep functions. Thus, it would be beneficial to assess the contribution of individual circuits in sleep's putative functions. The intricacy of the mammalian brain makes this task extremely difficult. However, the fruit fly Drosophila melanogaster, with its simpler brain organization, available connectomics, and unp

SUBMITTER: Jones JD 

PROVIDER: S-EPMC12135941 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature