A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.

ABSTRACT: Social investigation is a complex behavior essential for understanding the surrounding world and is impaired in some major neuropsychiatric disorders. Yet, little is known about whether and, if yes, how social investigation is encoded in a specific type of cortical neurons. Here, we generated a computer vision tool to track social behavior of naïve mice and categorized them as high versus low social states. We integrated a genetically guided TRAP2 strategy with single-cell Ca²⁺ image and found that activity dynamics of serotonin receptor 2c (Htr2c)-expressing neurons in the prelimbic cortical layer 5 encode high social states. We uncovered a long noncoding RNA Lrhcn1 that controls Hcn1 transcription and regulates ensemble activity of Htr2c neurons, and this regulation motivates

SUBMITTER: Qin P 

PROVIDER: S-EPMC12136044 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature