Low-level arsenic exposure, childhood neighborhood disadvantage, and executive functions in adolescents from Montevideo, Uruguay.

ABSTRACT:

Introduction

Low-level arsenic (As) exposure is linked to cognitive deficits, but its impact on specific executive functions (EF) in adolescents is not well understood. Additionally, neighborhood socioeconomic context may interact with As exposure to influence cognitive outcomes. This study examines associations between blood As levels, neighborhood disadvantage, and EF performance in adolescents from Montevideo, Uruguay.

Methods

We analyzed data from 344 adolescents in the Salud Ambiental Montevideo (SAM) cohort, where blood As levels were measured at two time points, with values averaged and log2-transformed for analysis. EFs, including working memory, inhibitory control, cognitive flexibility, and fluid cognition, were assessed using the NIH Cognitive Toolbox. Neighborhoo

SUBMITTER: Rodriguez D 

PROVIDER: S-EPMC12136979 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature