West African-South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems.

ABSTRACT: Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. The West African-South American (WASA) lineage of V. cholerae, responsible for the 1991-2001 Latin American cholera epidemic, is defined by two unique genetic signatures. Here we show that these signatures encode multiple distinct anti-phage defence systems. Firstly, the WASA-1 prophage encodes an abortive-infection system, WonAB, that renders the lineage resistant to the major predatory vibriophage ICP1, which, alongside other phages, is thought to restrict cholera epidemics. Secondly, a unique set of genes on the Vibrio seventh pandemic island II encodes an unusual modification-dependent restriction system targeting phages with modified genomes, and a

SUBMITTER: Adams DW 

PROVIDER: S-EPMC12137116 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature