Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1.

ABSTRACT: Clonal haematopoiesis of indeterminate potential (CHIP) involves the gradual expansion of mutant pre-leukaemic haematopoietic cells, which increases with age and confers a risk for multiple diseases, including leukaemia and immune-related conditions¹. Although the absolute risk of leukaemic transformation in individuals with CHIP is very low, the strongest predictor of progression is the accumulation of mutant haematopoietic cells². Despite the known associations between CHIP and increased all-cause mortality, our understanding of environmental and regulatory factors that underlie this process during ageing remains rudimentary. Here we show that intestinal alterations, which can occur with age, lead to systemic dissemination of a microbial metabolite that promotes pre

SUBMITTER: Agarwal P 

PROVIDER: S-EPMC12137129 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature