Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption.

ABSTRACT: Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes. Withaferin A (WA), a bioactive compound from Withania somnifera, has anticancer effects and can modulate cellular processes like autophagy and mitochondrial function. This study investigates WA's role in enhancing radiosensitivity by targeting apoptosis, autophagy, and mitochondrial function in SGC-7901 gastric cancer cells. In both in vitro and in vivo models, combined WA and radiation (IR) treatment significantly inhibited tumor growth, as evidenced by reduced tumor size in xenografts. Mechanistically, this combination promoted apoptosis, with increased levels of cleaved caspase-3 and PARP

SUBMITTER: Lu P 

PROVIDER: S-EPMC12137800 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature