Connection between circulating inflammatory cytokines and non-small cell lung cancer: integrated Mendelian randomization and gene function analysis.

ABSTRACT:

Background

A lot of cancers including non-small cell lung cancer (NSCLC) arise in association with chronic inflammation. In this study, Mendelian randomization (MR) and gene function analyses were integrated to address the connection between circulating inflammatory cytokines and NSCLC, and the underlying biological processes and functional significance of the correlated inflammatory cytokines.

Methods

We employed the summary statistics of 91 inflammatory cytokines and NSCLC from the genome-wide association studies. The bidirectional MR analysis was used to identify cytokines causally associated with NSCLC. The Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) and Gene Set Enrichment Analysis (GSEA) were used to explore the biological pathways and functional

SUBMITTER: Niu K 

PROVIDER: S-EPMC12137847 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature