Polysaccharides of Atractylodes macrocephala Koidz alleviate bursa of Fabricius involution in Magang geese by inhibiting the Wnt signaling pathway.

ABSTRACT: Involution of the bursa of Fabricius (BF) with increasing age in avian species leads to decreases in lymphocyte counts and pathogen recognition, thereby compromising immune function and increasing susceptibility to infections. Polysaccharides of Atractylodes macrocephala Koidz (PAMK), a major component of the traditional Chinese medicine Atractylodes macrocephala, increase immunity. This study aimed to explore the impact of PAMK on the BF during involution in Magang geese. Following the prefeeding period, 54 four-month-old Magang geese were selected for the experiment. These geese were evenly divided into three groups. Each group consisted of three replicates, with six geese per replicate. One group was immediately euthanized to collect serum and BF samples. The remaining 36 geese were fur

SUBMITTER: Liang W 

PROVIDER: S-EPMC12138414 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature