Age- and sex-differences and reference values for ventricular strain by cardiovascular magnetic resonance imaging in adults without cardiovascular disease or cardiovascular disease risk factors.

ABSTRACT:

Background

Myocardial deformation measured by myocardial strain is an important marker of cardiovascular disease (CVD). We aimed to establish normal values and examine age- and sex-differences in left and right ventricular (LV, RV) strain using feature tracking cardiovascular resonance (FT-CMR) in adults free of CVD in the community.

Methods

Framingham Heart Study Offspring participants without CVD, hypertension, or diabetes completed CMR (1.5T) (n=903, 59% (533/903) women, 36-88 years of age). Global longitudinal, circumferential, and radial strain (GLS, GCS, and GRS, respectively) were measured by semi-automated LV and RV myocardial segmentation of short-axis, 2-chamber, and 4-chamber images with cvi42 (v.5.13, Circle Cardiovascular Imaging, Calgary, Canada).

Results

SUBMITTER: Pillai R 

PROVIDER: S-EPMC12138549 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature