Synthetic extracellular volume fraction as an imaging biomarker of the myocardial interstitium without blood sampling: a systematic review and meta-analysis.

ABSTRACT:

Background

The calculation of conventional extracellular volume fraction (ECV) requires blood hematocrit (Hct) measurement. Based on the relationship between Hct and blood T1 relaxivity for cardiac magnetic resonance (CMR), a synthetic ECV could be estimated without a blood sampling. The aim of this study was to evaluate the correlation and agreement in the quantification of synthetic ECV and laboratory ECV from conventional Hct measurements.

Methods

Electronic database searches of PubMed, Web of Science Core Collection, Cochrane advanced search, and EMBASE were performed. The authors employed a meta-analysis using the generic inverse variance method with a random-effects model to estimate the summary correlation coefficient and mean absolute difference between synthetic and

SUBMITTER: Yasuda N 

PROVIDER: S-EPMC12138551 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature