Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial.

ABSTRACT:

Importance

Major depressive disorder (MDD) and obesity are common noncommunicable disorders associated with substantial disease burden, which frequently occur comorbidly. Intriguingly, converging lines of evidence from animal models and genetic and observational studies have suggested a biological link between obesity, metabolic syndrome, and depression. Several small randomized clinical trials (RCTs) have suggested the antidepressive potential of statins.

Objective

To examine whether simvastatin added to escitalopram is efficacious in improving depressive symptoms compared with add-on placebo.

Design, setting, and participants

This was a confirmatory, double-blind, placebo-controlled, multicenter RCT. Adults with MDD and comorbid obesity from 9 tertiary care settings

SUBMITTER: Otte C 

PROVIDER: S-EPMC12138799 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature