Oral Management Improves Patient Outcomes in Hematopoietic Stem Cell Transplantation.

ABSTRACT:

Introduction and aims

Oral bacteria influence bloodstream infections in hematopoietic stem cell transplantation (HSCT). We investigated the effects of oral health management and its relationship with medical care delivery systems.

Methods

Patients aged >16 years who underwent HSCT, discharged from Japanese acute care hospitals between April 2018 and March 2022, were categorized into autologous and allogeneic HSCT groups. Multivariable analysis assessed the impact of peri-HSCT oral management on antibiotic use, narcotic injections, and mortality rates.

Results

We included 12,248 patients, 5936 autologous and 6312 allogeneic HSCT patients, across 298 hospitals. The defined daily dose (DDD) of antibiotic use within 14 days post-transplantation in the oral and nonoral man

SUBMITTER: Moriwaki M 

PROVIDER: S-EPMC12139409 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature