Calcium calmodulin kinase IV deficiency in podocytes prevents the development of lupus nephritis.

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread organ involvement including the kidney. Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to conrol immune cell nad podocyte function. To address the effect of genetic podocyte-specific CaMK4 deficiency on systemic autoimmunity and kidney pathology in lupus-prone mice we generated B6.lpr.Camk4^flox.^.podocin^cre mice. Although podocyte-specific CaMK4 deletion in the lupus-prone Br.lpr mice did not affect systemic autoimmune response parameters, it led to significant improvement of kidney pathology and clinical outcomes. Specifically, B6.lpr.Camk4^flox.^.podocin^cre mice exhibited reduced glomerular pathology, characte

SUBMITTER: Bhargava R 

PROVIDER: S-EPMC12139444 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature