Association of impaired kidney function with dementia and brain pathologies: A community-based cohort study.

ABSTRACT:

Introduction

The relationship between impaired kidney function (KF), dementia, and brain pathologies remains unclear.

Methods

A total of 1354 dementia- and kidney disease-free participants including 895 with normal and 459 with impaired KF were followed from 2002 until 2020 (median [interquartile range]: 5 [2-9]) to detect incident dementia. KF was assessed at baseline and categorized as normal or impaired. Over the follow-up, 453 participants died and underwent autopsies for neuropathological assessment.

Results

Compared to those with normal KF, the hazard ratios (95% confidence intervals [CIs]) of those with impaired KF was 1.48 (1.15, 1.90)/1.44 (1.10, 1.88) for dementia/Alzheimer's dementia. Furthermore, impaired KF was related to a significantly higher burden of

SUBMITTER: Wang S 

PROVIDER: S-EPMC12139445 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature