Translational buffering tunes gene expression in mouse and human.

ABSTRACT: Translational buffering refers to the regulation of ribosome occupancy to offset the effects of transcriptional variation. While previous work systematically analyzed translational buffering in yeast, it remains unknown whether this is an intrinsic property of genes in mouse and human across cell types. To identify this phenomenon on a global scale and across different experimental conditions, we uniformly analyzed 1515 matched ribosome profiling and RNA-seq datasets from human and mouse tissues or cell lines. This resource enabled us to assess the potential of genes to exhibit translational buffering by comparative analysis of variation at ribosome occupancy and the RNA levels across cell types as well as by examining the relationship between mRNA abundance and translation efficiency. We

SUBMITTER: Rao S 

PROVIDER: S-EPMC12139725 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature