Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.

ABSTRACT: Diffuse gliomas remodel neuronal circuits with prognostic and therapeutic significance for patients. Electrophysiologic measures of cortical excitability hold promise for monitoring disease progression and evaluating therapeutic responses. The power law exponent (aperiodic slope) reflects the balance between excitatory and inhibitory activity within neuronal networks, a critical aspect of normal brain function often disrupted in neurological conditions. Despite its potential, the significance of the aperiodic slope in glioma-infiltrated tissue and its underlying cellular processes has not been fully investigated. Here, we integrate multimodal electrophysiological analysis with transcriptomic profiling to analyze the aperiodic slope in both normal and glioma-infiltrated cortex. We determine

SUBMITTER: Sibih YE 

PROVIDER: S-EPMC12139770 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature