Methamphetamine modulates functional connectivity signatures of sustained attention and arousal.

ABSTRACT: Building on evidence that psychostimulants modulate whole-brain functional connectivity signatures of sustained attention, we examined how a single dose of methamphetamine (MA, 20 mg) changes network-level functional organization and sustained attention in healthy adults. Using a within-subject, placebo-controlled design, we tested whether MA selectively affects behavioral and fMRI connectivity signatures of sustained attention and arousal. Under MA, participants showed improved sustained attention task performance as well as functional connectivity signatures of higher sustained attention and arousal. These network changes emerged consistently across resting-state and task-based fMRI, indicating that MA influences attention- and arousal-related networks regardless of cognitive context. Fu

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC12139791 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature