Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity.

ABSTRACT: Applicable methods of rejuvenating organisms and improving resistance to environmental stimuli are needed. During attempts to synchronize heart rates in unhealthy colonial chordates, we observed morphological rejuvenation. While the importance of endogenously generated bioelectric currents in development is well-established^1,2, and exogenously applied current has shown promise in regenerative medicine^{3,4,5,6,7,8,9}, a model that robustly increases longevity and fertility while providing detailed mechanistic insights has not been reported. Here, we report the establishment of such a model using pulsatile electrical current (PEC) in Botryllus schlosseri, an established colonial chordate model^{10,11,12,13,14,15}. PEC treatment significantly improved surviv

SUBMITTER: Domen J 

PROVIDER: S-EPMC12139841 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature