Seizure Circuit Activity in the Theiler's Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations.

ABSTRACT: Epilepsy affects one in twenty-six individuals. A major cause of epilepsy worldwide is viral encephalitis. Central nervous system infections can provoke seizures in the short term and increase the risk of spontaneous, recurrent seizures post-infection. However, the neural mechanisms underlying seizures during acute infection are unknown. These neuronal changes can be studied in C57BL6/J mice infected with Theiler's murine encephalomyelitis virus (TMEV). TMEV-infected mice experience seizures 3-8 days post-injection (DPI), clear the virus by DPI 14, and may develop chronic, acquired temporal lobe epilepsy. TMEV may incite seizures during the acute infection period through inflammation, reactive gliosis, and cell death in hippocampal area CA1. Here, we explore the neuronal circuits underlyin

SUBMITTER: Petrucci AN 

PROVIDER: S-EPMC12139844 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature