Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT₁ Receptor Expression.

ABSTRACT:

Introduction

The renin-angiotensin-aldosterone system (RAAS) has been shown to be dysregulated in dementia, with elevated levels of angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptors (AT₁Rs). Cerebral amyloid angiopathy (CAA), a common cerebrovascular disease, currently has no treatment or cure available. We aimed to determine if a mouse model with CAA (Tg-SwDI) also exhibits elevated levels of AT₁Rs and whether RAAS-targeting drugs (telmisartan and lisinopril) mitigate these effects.

Materials and methods

Tg-SwDI mice were treated with sub-depressor doses of either telmisartan or lisinopril from 3-8 months of age, with blood pressure being monitored 2 and 4 months after the start of treatment. Postmortem, receptor au

SUBMITTER: Noto NM 

PROVIDER: S-EPMC12139886 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature