MRAS: Master Regulator Analysis of Alternative Splicing.

ABSTRACT: As a molecular feature that characterizes most tumor types, cancer-associated splicing dysregulation largely arises from recurrent genetic mutations and altered expression of trans-acting splicing factors. Although splicing factor mutations occur less frequently in solid tumors, splicing disorders are pervasive and proven to promote tumorigenesis. However, it still lacks an efficient way to identify the key splicing factors at the top regulatory hierarchy whose abnormal expressions induce such splicing disorders and drive phenotypic variability. Here, MRAS (Master Regulator analysis of Alternative Splicing) is introduced, a computational method designed to pinpoint the pivotal splicing factors that play a central role in shaping splicing regulatory networks and influencing cellular process

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12140307 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature