Targeting miRNA-1a and miRNA-15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration.

ABSTRACT: Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio-temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the strict post-mitotic state of human adult cardiomyocytes. To address this unmet therapeutic need, a combinatorial miRNA interference screen is performed specifically targeting cardiac-predominant miRNAs regulating key aspects of cardiomyocyte mitotic induction to cell-cycle completion in neonatal rat cardiomyocytes. In doing so combinatorial interference of miRNA-1a and miRNA-15b (LNA-1a/15b) is identified as drivers of adult cardiomyocyte proliferation. Due to miRNA-1a/15b function on multiple processes modulating adult cardiomyocyte mitosis, its inhibitio

SUBMITTER: Yuan T 

PROVIDER: S-EPMC12140343 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature