Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease.

ABSTRACT: Proliferation of microglia represents a physiological process, which is accelerated in several neurodegenerative disorders including Alzheimer disease (AD). The effect of such neurodegeneration-associated microglial proliferation on function and disease progression remains unclear. Here, we show that proliferation results in profound alterations of cellular function by providing evidence that newly proliferated microglia show impaired beta-amyloid clearance in vivo. Through sorting of proliferating microglia of APP/PS1 mice and subsequent transcriptome analysis, we define unique proliferation-associated transcriptomic signatures that change with age and beta-amyloid accumulation and are characterized by enrichment of immune system-related pathways. Of note, we identify the DEAD-Box Helicas

SUBMITTER: Villacampa N 

PROVIDER: S-EPMC12140498 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature