Understanding the Epidemiology of Malaria in Zanzibar through Molecular and Serological Analysis of Samples collected during Reactive Case Detection.

ABSTRACT:

Background

The Zanzibar archipelago has been a pre-elimination region for malaria thanks to rigorous control interventions, but recent surges in malaria cases have been observed. The contribution of non-falciparum species to the current malaria situation is unknown.

Methods

This study investigates the seroepidemiology of falciparum and non-falciparum malaria species in Zanzibar. Leveraging plasma extracted from dried blood spots (DBS) collected during reactive case detection (RCD) activities across Unguja island from May 2022 to May 2023, we measured immunoglobulin G (IgG) responses to Plasmodium MSP1-19kD antigens using a multiplex bead-based immunoassay. Additionally, active infections were detected using species-specific real-time PCR.

Results

Out of 1,618 p

SUBMITTER: Goel V 

PROVIDER: S-EPMC12140523 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature