Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain.

ABSTRACT: Spontaneous pain, characterized by episodic shooting or stabbing sensations, is a major complaint among neuropathic pain patients, yet its mechanisms remain poorly understood. Recent research indicates a connection between this pain condition and "clustered firing," wherein adjacent sensory neurons fire simultaneously. This study presents evidence that the triggers of spontaneous pain and clustered firing are the dynamic movements of small blood vessels within the nerve-injured sensory ganglion, along with increased blood vessel density/angiogenesis and increased number of pericytes around blood vessels. Pharmacologically or mechanically evoked myogenic vascular responses increase both spontaneous pain and clustered firing in a mouse model of neuropathic pain. The mechanoreceptor Piezo2 in

SUBMITTER: Xie W 

PROVIDER: S-EPMC12140901 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature