Donor-specific digital twin for living donor liver transplant recovery.

ABSTRACT: The remarkable capacity of the liver to regenerate its lost mass after resection makes living donor liver transplantation a successful treatment option. However, donor heterogeneity significantly influences recovery trajectories, highlighting the need for individualized monitoring. With the rising incidence of liver diseases, safer transplant procedures and improved donor care are urgently needed. Current clinical markers provide only limited snapshots of recovery, making it challenging to predict long-term outcomes. Following partial hepatectomy, precise liver mass recovery requires tightly regulated hepatocyte proliferation. We identified distinct gene expression patterns associated with liver regeneration by analyzing blood-derived gene expression measurements from twelve donors followe

SUBMITTER: Halder S 

PROVIDER: S-EPMC12141195 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature