TRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2.

ABSTRACT:

Introduction

Nasopharyngeal carcinoma (NPC) is highly aggressive, with a particularly high incidence in South China. is an aggressive cancer that affects particularly high numbers of patients in southern China and Southeast Asia. The cure rate of previous treatments is decreasing year by year, underscoring the need to devise new approaches to treating affected patients. This study was developed to examine the tRF-1:28-Val-CAC-2 expression in NPC and to elucidate its effects on proliferative, migratory, and apoptotic dynamics in NPC cells.

Methods

RT- qPCR was used to quantify tRF-1:28-Val-CAC-2 expression in NPC cells. Transfection was used to manipulate tRF-1:28-Val-CAC-2 expression levels, and proliferation, migration, and invasion were then evaluated through CCK-8, wound-

SUBMITTER: Li H 

PROVIDER: S-EPMC12141329 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature