Functional brain network correlates of cardiorespiratory fitness and moderation by depression symptoms.

ABSTRACT: Cardiorespiratory fitness may protect against or alleviate depression through neuroplastic mechanisms within disrupted brain networks underlying cognitive and affective symptoms. There is a scarcity of research examining the effects of cardiorespiratory fitness on functional brain networks in representative samples spanning adulthood. Further, little is known about the interaction of cardiorespiratory fitness with depression in these networks. To address this problem, this study made use of the NKI-Rockland sample dataset and magnetic resonance imaging to examine whether functional brain network features associated with cardiorespiratory fitness were moderated by depression symptom severity in a community sample of 217 participants (134 females, 83 males) between the ages of 18 and 71 (M =

SUBMITTER: Borrell LR 

PROVIDER: S-EPMC12141363 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature