Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans.

ABSTRACT: The ability to adhere to surfaces and develop as a multicellular community is an adaptation used by most microorganisms to survive in changing environments. Biofilm formation proceeds through distinct developmental phases and impacts not only medicine but also industry and evolution. In organisms such as the opportunistic pathogen Candida albicans, the ability to grow as biofilms is also an important mechanism for persistence, facilitating its growth on different tissues and a broad range of abiotic surfaces used in medical devices. The early stage of C. albicans biofilm is characterized by the adhesion of single cells to the substratum, followed by the formation of an intricate network of hyphae and the beginning of a dense structure. Changes in the transcriptome begin within 30 min of co

SUBMITTER: Murillo LA 

PROVIDER: S-EPMC1214198 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature