Transbronchial cryobiopsy alone versus combined with traditional forceps biopsy for acute cellular rejection in lung transplant recipients. A diagnostic randomized trial.

ABSTRACT:

Background

Transbronchial lung biopsy is routinely performed to identify acute cellular rejection (ACR) in lung transplant recipients (LTRs). This trial evaluates the clinical value of forceps and cryobiopsies versus cryobiopsies as a standalone diagnostic tool.

Methods

In this randomized trial, LTRs were randomly assigned to receive either 2 cryobiopsies (cryobiopsy group) or a combination of 5 forceps- and 2 cryobiopsies (combined group). The primary outcome was the diagnostic yield to detect ACR; the secondary outcome was the incidence of ACR. We conducted a paired, intraindividual comparison in the combined group alongside interindividual comparisons.

Results

A total of 80 LTRs were randomly assigned to the cryobiopsy group (n = 40) or the combined group (<

SUBMITTER: Steinack C 

PROVIDER: S-EPMC12142631 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature