Characterization of Additive Gene-environment Interactions For Colorectal Cancer Risk.

ABSTRACT:

Background

Colorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of critical public health importance. Previous studies have assessed multiplicative interaction between genetic risk scores and environmental factors, but few have assessed additive interaction, the relevant public health measure.

Methods

Using resources from CRC consortia, including 45,247 CRC cases and 52,671 controls, we assessed multiplicative and additive interaction (relative excess risk due to interaction, RERI) using logistic regression between 13 harmonized environmental factors and genetic risk score, including 141 variants associated with CRC risk.

Results

There was no evidence of multiplicative interaction between environmental fact

SUBMITTER: Thomas CE 

PROVIDER: S-EPMC12142706 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature