Longitudinal Lipid Trajectories and Progression of CKD in Children.

ABSTRACT:

Introduction

There are discrepant findings regarding the effect of dyslipidemia on disease progression in adult patients with chronic kidney disease (CKD).

Methods

In a prospective cohort study of children with stage 3 to 5 (predialysis) CKD, triglycerides (TGs), total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured semiannually. We investigated whether CKD progression is associated with serum lipid levels at baseline and with lipid trajectories during follow-up. CKD progression was defined as the time to a composite event of 50% reduction in estimated glomerular filtration rate (eGFR), eGFR < 10 ml/min per 1.73 m², or start of kidney replacement therapy. By semiparametric group-based

SUBMITTER: Querfeld U 

PROVIDER: S-EPMC12142784 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature