HDAC9-Mediated Pyroptosis Promotes Orthodontically Induced Inflammatory Root Resorption.

ABSTRACT:

Introduction and aims

Orthodontically induced inflammatory root resorption (OIIRR) is a common iatrogenic outcome of orthodontic treatment. Both epigenetic modifications and pyroptosis have demonstrated a certain role in OIIRR. This study aims to investigate whether epigenetic modifications regulate pyroptosis to be involved in OIIRR.

Method

Rat model of OIIRR was established, and the periodontal tissues were utilized for H&E staining, TRAP staining, immunofluorescence, transcriptome sequencing, and RT-qPCR analysis. Human periodontal ligament fibroblasts (hPDLFs) were overexpressed with HDAC9, treated with pyroptosis inhibitor, incubated with osteoclast, and then subjected to CUT&Tag sequencing.

Results

Orthodontic force increased the distance of orthodontic tooth mo

SUBMITTER: Chen L 

PROVIDER: S-EPMC12142796 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature