An unconventional T cell nexus drives HCK-mediated chronic obstructive pulmonary disease in mice.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory lung disease leading to progressive, destructive lung function decline, disability and death, and it is refractory to all current treatments. Haematopoietic cell kinase (HCK) is a druggable SRC-family non-receptor protein tyrosine kinase and COPD candidate gene. It is implicated in the chronic and non-resolving inflammation that causes mucosecretory bronchitis and destruction of small airways and alveoli, but how it drives pathophysiology remains obscure.

Methods

Studies primarily utilised gene-targeted mice with a gain-of-function mutation in Hck that rendered the enzyme constitutively active. Bone marrow chimeras were established to determine the origin of disease, and the lung disease

SUBMITTER: Hsu AT 

PROVIDER: S-EPMC12143211 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature