The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration.

ABSTRACT: Lung epithelial progenitors use a complex network of known and predicted transcriptional regulators to influence early lung development. In this study, we evaluated the function of one predicted regulator, CUX1, that we identified from transcriptional regulatory analysis of the SOX9⁺ distal lung progenitor network. We generated a new Cux1-floxed mouse model and created an epithelium-specific knockout of CUX1 using Shh-Cre (Cux1^ShhCre-LOF). Postnatal Cux1^ShhCre-LOF animals recapitulated key skin phenotypic features found in prior constitutive CUX1 knockout animals, confirming the functionality of our new floxed model. Postnatal Cux1^ShhCre-LOF mice displayed subtle alveolar simplification and a transient delay in alveologenesis and al

SUBMITTER: Zhao B 

PROVIDER: S-EPMC12143410 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature