KRAS regulates IL-17 signal activity by affect the metastasis of osteosarcoma via an IL-17A-dependent manner.

ABSTRACT: Dysregulation of Kirsten rat sarcoma virus (KRAS) plays crucial roles in many tumors. It is reported that KRAS could promote proliferation of osteosarcoma (OS) cells. Nonetheless, the contribution of KRAS to the invasion and spread of OS is still not well understood. This study aimed to investigate KRAS-driven metastasis and the mechanisms behind it in human OS. Tissue microarrays were utilized to assess KRAS expression and its relationship with clinicopathological characteristics. The migratory and invasive abilities of OS cells were evaluated through wound-healing assays and transwell analysis. Furthermore, the regulatory mechanisms of KRAS in human OS were analyzed using RNA sequencing, tandem mass tags assays, multiple immunofluorescence assays, micro-CT, and bioluminescence imaging. I

SUBMITTER: Bao X 

PROVIDER: S-EPMC12143473 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature