Causal relationship between physical activity, sleep duration, sedentary behavior, and hypertension: A Mendelian randomisation study.

ABSTRACT:

Background

Lifestyle behaviors may be an important means of preventing hypertension. The causal relationship between physical activity, sleep duration, sedentary behavior, and hypertension remains unclear. The aim of this study was to examine these associations by using Mendelian randomization (MR) analysis.

Materials and methods

Single nucleotide polymorphisms associated with sedentary behavior patterns (including length of mobile phone use, time spent driving, time spent watching television, and time spent playing computer games), duration of walks, sleep duration, and moderate-to-vigorous intensity physical activity (MVPA) at genome-wide significance (P < 5 × 10^-8) were selected as instrumental variables (IVs) from a genome-wide association study. These

SUBMITTER: Wang C 

PROVIDER: S-EPMC12143605 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature