Multi-omics analysis provides new insights into the molecular mechanisms underlying colostral immunoglobulin G absorption in the gut of neonatal goat kids.

ABSTRACT: Early colostrum feeding facilitates the passive transfer of immunoglobulin G (IgG), which contributes to the defensive establishment of neonates; however, the molecular mechanisms of IgG absorption in the small intestine of neonatal mammals remain largely unknown. In this study, a total of 16 neonatal goat kids with similar body weight (2.05 ± 0.31 kg) were selected and randomly assigned to 1 of 2 feeding treatments: normal colostrum feeding (NCF, n = 8) or delayed colostrum feeding (DCF, n = 8). Multi-omics coupled with individual bioinformatics analyses were employed to obtain a comprehensive understanding of the molecular mechanisms of IgG absorption. Phenotypic analysis showed that the capacity of IgG absorption was largely affected (P < 0.05) by colostrum feeding

SUBMITTER: Yang C 

PROVIDER: S-EPMC12143632 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature