The Endocannabinoid System Drives Eosinophil Infiltration During Eosinophilic Esophagitis.

ABSTRACT:

Background and aims

Eosinophilic esophagitis (EoE) is a chronic, inflammatory, and antigen-driven disease of the esophagus. Total transcriptome data revealed alterations in the endocannabinoid system, in particular, down-regulation of monoacylglycerol lipase (MGL) in biopsies of patients with active EoE. We investigated the consequence of MGL down-regulation in mucosal biopsies of patients, and its implications for EoE development, such as recruitment of eosinophils.

Methods

Levels of MGL substrate 2-arachidonoylglycerol, MGL enzyme activity, and MGL colocalization with epithelial cells were determined in mucosal esophageal biopsies of patients with EoE. Supernatant of human primary esophageal epithelial cells was used to determine eosinophil migration and activation. An ind

SUBMITTER: Gruden E 

PROVIDER: S-EPMC12143766 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature