CD38 contributes to tumor progression and tumor microenvironment reshaping in epithelial ovarian cancer.

ABSTRACT:

Background

Ovarian cancer, ranking fifth in cancer mortality, presents a significant therapeutic challenge. The immunomodulatory functions of CD38in epithelial ovarian cancer (EOC) and its influence on the tumor microenvironment (TME) remain poorly understood.

Methods

Public datasets, RT-qPCR and immunohistochemistry (IHC) were used to analyze CD38 expression and clinicopathological features in EOC. Gene manipulation techniques were employed to elucidate its functions, while integrated IHC and bioinformatics were conducted to assess its involvement in immune/stromal infiltration. Immune-related functions of CD38 were explored using GO, KEGG analysis and TIP database. TIDE algorithm was employed to predict the correlation between CD38 and immune checkpoint blocking responsive

SUBMITTER: Wang W 

PROVIDER: S-EPMC12143800 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature