Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington's disease: a [¹⁸F]SynVesT-1 study.

ABSTRACT: Huntington's disease (HD) is a neurodegenerative disorder characterized by involuntary movements, cognitive decline and psychiatric problems. HD has been associated with synaptic dysfunction and loss of the synaptic vesicle protein 2A (SV2A). SV2A can readily be quantified via positron emission tomography (PET) using the selective and high affinity SV2A radiotracer [¹⁸F]SynVesT-1 that we previously characterized in C57BL/6J mice. Here, we performed dynamic [¹⁸F]SynVesT-1 PET to characterize SV2A levels at various disease stages in another HD mouse model, zQ175DN, at 3 and 6 months (M) (longitudinal) and 10 M and 16 M (cross-sectional). We also conducted ex vivo SV2A immunofluorescent staining and [³H]UCB-J and [³H]SynVesT-1 autoradiography at 16 

SUBMITTER: Everix L 

PROVIDER: S-EPMC12143836 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature