Developmental features and unique characteristics of peptide-specific PLZF⁺ innate-like T cells in mice.

ABSTRACT: Peptide-specific PLZF⁺ innate-like T (PILT) cells are a member of the innate-like T cell family utilizing a diverse set of T cell receptor (TCR) Vβ chains. Yet there are no present studies providing clues into the developmental features of PILT cells at a transcriptome level. Here, we performed single-cell transcriptomic analyses of PILT cells and compared them to other members of the innate-like T cell family. We show that PILT cells share similar transcriptional profiles and overlapping developmental trajectories with invariant Natural Killer T (iNKT) cells. However, in contrast to iNKT cells, PILT cells display a polyclonal TCR repertoire closely resembling the one of conventional CD8 T cells, inferring MHC I restriction and a broader range of antigen specificity. We further

SUBMITTER: Hassan A 

PROVIDER: S-EPMC12144119 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature