Effects of Plasmodium berghei infection on the expression of salivary gland immune-related genes in the Anopheles stephensi mosquito.

ABSTRACT:

Background

Achieving malaria eradication by 2050 will require the development of novel transmission-blocking strategies alongside existing and emerging control measures. Since the innate immune responses of Anopheles salivary glands determine its vectorial capacity, a detailed assessment of vector-parasite interactions could help identify novel targets that play key roles in the immune response against Plasmodium. In this study, six candidate immune-related genes from Anopheles stephensi salivary gland transcriptomic datasets were selected, and their expression changes were assessed following Plasmodium berghei infection.

Methods

Using RT-qPCR, gene expression profiles at 18 days (early phase) and 21 days (late phase) post-infection were analysed, and the results were compar

SUBMITTER: Pirahmadi S 

PROVIDER: S-EPMC12144816 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature