Copper-dependent halogenase catalyses unactivated C-H bond functionalization.

ABSTRACT: Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp³)-H bond^1-3. In recent years, metalloenzymes have been found to perform C(sp³)-H bond functionalization^4,5. Despite substantial progresses in the past two decades^6,7, enzymatic halogenation and pseudohalogenation of unactivated C(sp³)-H-providing a functional handle for further modification-have been achieved with only non-haem iron/α-ketoglutarate-dependent halogenases, and are therefore limited by the chemistry possible with these enzymes⁸. Here we report the discovery and characterization of a previously unkn

SUBMITTER: Chiang CY 

PROVIDER: S-EPMC12145154 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature