NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is a highly prevalent and deadly disease that is largely refractory to immunotherapy. The only CRC subset that responds to these therapies is characterized by prevalent microsatellite instability (MSI), extensive  CD8+ T cell infiltration and high expression of innate immune signaling pathways. Endogenous activation of the cGAS/STING pathway is essential for this CD8+ T cell antitumor response in MSI CRCs, suggesting that activating it in other CRCs could boost immunotherapy response rates. In contrast, activation of the NLRP3 inflammasome is typically associated with tumor-promoting inflammation although this has primarily been studied in immune cells.

Methods

We used a mixture of flow cytometry, activation assays, in vivo orthotopic mod

SUBMITTER: Mowat C 

PROVIDER: S-EPMC12145389 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature